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World Health Organisation: Diabetes

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IDF Diabetes atlas, 8th edition, 2017

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ADA diabetes treatment guideline 2016: Diabetes care 2016 volume 39, S1

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Ismail-Beigi F, Craven T, Banerji MA, Basile J, Calles J, Cohen RM, Cuddihy R, Cushman WC, Genuth S, Grimm RH Jr, Hamilton BP, Hoogwerf B, Karl D, Katz L, Krikorian A, O'Connor P, Pop-Busui R, Schubart U, Simmons D, Taylor H, Thomas A, Weiss D, Hramiak I; ACCORD trial group. Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial. Lancet. 2010 Aug 7;376(9739):419-30. doi: 10.1016/S0140-6736(10)60576-4. Epub 2010 Jun 30. Erratum in: Lancet. 2010 Oct 30;376(9751):1466. PubMed PMID: 20594588; PubMed Central PMCID: PMC4123233.

4) BACKGROUND: Hyperglycaemia is associated with increased risk of cardiovascular complications in people...

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ADVANCE Collaborative Group, Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M, Marre M, Cooper M, Glasziou P, Grobbee D, Hamet P, Harrap S, Heller S, Liu L, Mancia G, Mogensen CE, Pan C, Poulter N, Rodgers A, Williams B, Bompoint S, de Galan BE, Joshi R, Travert F. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008 Jun 12;358(24):2560-72. doi: 10.1056/NEJMoa0802987. Epub 2008 Jun 6. PubMed PMID: 18539916.



5) BACKGROUND: In patients with type 2 diabetes, the effects of intensive glucose control on vascular...

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Duckworth W, Abraira C, Moritz T, Reda D, Emanuele N, Reaven PD, Zieve FJ, Marks J, Davis SN, Hayward R, Warren SR, Goldman S, McCarren M, Vitek ME, Henderson WG, Huang GD; VADT Investigators. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2009 Jan 8;360(2):129-39. doi: 10.1056/NEJMoa0808431. Epub 2008 Dec 17. Erratum in: N Engl J Med. 2009 Sep 3;361(10):1028. N Engl J Med. 2009 Sep 3;361(10):1024-5. PubMed PMID: 19092145.




6) BACKGROUND: The effects of intensive glucose control on cardiovascular events in patients with long-standing...

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Colagiuri S. Glycated haemoglobin (HbA1c) for the diagnosis of diabetes mellitus--practical implications. Diabetes Res Clin Pract. 2011 Sep;93(3):312-3. doi: 10.1016/j.diabres.2011.06.025. Epub 2011 Aug 5. PubMed PMID: 21820751.


7) Diagnosing diabetes is a common clinical challenge. Published in this issue of the journal is the report of the WHO consultation on ...

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Diabetes Control and Complications Trial Research Group, Nathan DM, Genuth S, Lachin J, Cleary P, Crofford O, Davis M, Rand L, Siebert C. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993 Sep 30;329(14):977-86. PubMed PMID: 8366922.

8) BACKGROUND: Long-term microvascular and neurologic complications cause major morbidity and mortality in patients with ...

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Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998 Sep 12;352(9131):854-65. Erratum in: Lancet 1998 Nov 7;352(9139):1558. PubMed PMID: 9742977.

9) BACKGROUND: In patients with type 2 diabetes, intensive blood-glucose control with insulin or sulphonylurea therapy ...

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Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, Hadden D, Turner RC, Holman RR. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000 Aug 12;321(7258):405-12. PubMed PMID: 10938048; PubMed Central PMCID: PMC27454

10) OBJECTIVE: To determine the relation between exposure to glycaemia over time and the risk of macrovascular ...

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Clarke P, Gray A, Adler A, Stevens R, Raikou M, Cull C, Stratton I, Holman R; UKPDS Group. United Kingdom Prospective Diabetes Study. Cost-effectiveness analysis of intensive blood-glucose control with metformin in overweight patients with type II diabetes (UKPDS No. 51). Diabetologia. 2001 Mar;44(3):298-304. PubMed PMID: 11317659.

11) AIMS/HYPOTHESIS: To estimate the economic efficiency of intensive blood-glucose control with metformin ...

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Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008 Oct 9;359(15):1577-89. doi: 10.1056/NEJMoa0806470. Epub 2008 Sep 10. PubMed PMID: 18784090.


12) BACKGROUND: During the United Kingdom Prospective Diabetes Study (UKPDS), patients with type 2 diabetes ...

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Skyler JS, Bergenstal R, Bonow RO, Buse J, Deedwania P, Gale EA, Howard BV, Kirkman MS, Kosiborod M, Reaven P, Sherwin RS; American Diabetes Association; American College of Cardiology Foundation; American Heart Association. Intensive glycemic control and the prevention of cardiovascular events: implications of the ACCORD, ADVANCE, and VA Diabetes Trials: a position statement of the American Diabetes Association and a Scientific Statement of the American College of Cardiology Foundation and the American Heart Association. J Am Coll Cardiol. 2009 Jan 20;53(3):298-304. doi: 10.1016/j.jacc.2008.10.008. Review. PubMed PMID: 19147051

13) Diabetes is defined by its association with hyperglycemia-specific microvascular complications; however, ...

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Werner A, Bell J: The preparation of methylguanidine and of ßß-dimethylguanidineby the interaction of dicyanodiamide and methylammonium anddimethyammonium chlorides respectively. Journal of the Chemical SocietyTransactions 1922: 121: 1790-4











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Graham GG, Punt J, Arora M, Day RO, Doogue MP, Duong JK, Furlong TJ, Greenfield JR, Greenup LC, Kirkpatrick CM, Ray JE, Timmins P, Williams KM. Clinical pharmacokinetics of metformin. Clin Pharmacokinet. 2011 Feb;50(2):81-98. doi: 10.2165/11534750-000000000-00000. Review. PubMed PMID: 21241070







15) Metformin is widely used for the treatment of type 2 diabetes mellitus. It is a biguanide developed from galegine, ...

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Fujioka, K., Pans, M., & Joyal, S. (2003). Glycemic control in patients with type 2 diabetes mellitus switched from twice-daily immediate-release metformin to a once-daily extended-release formulation. Clinical Therapeutics, 25(2), 515–529. doi:10.1016/s0149-2918(03)80093-0

16) BACKGROUND: The extended-release formulation of metformin (MXR) prolongs drug absorption in the upper gastrointestinal ...

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Zong J, Borland J, Jerva F, Wynne B, Choukour M, Song I. The effect of dolutegravir on the pharmacokinetics of metformin in healthy subjects. J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19584. doi: 10.7448/IAS.17.4.19584. eCollection 2014. PubMed PMID: 25394090; PubMed Central PMCID: PMC4224846.

17) Dolutegravir (DTG) is an HIV integrase strand transfer inhibitor approved for use in combination with other antiretrovirals for the ...

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Campbell JM, Bellman SM, Stephenson MD, Lisy K. Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis. Ageing Res Rev. 2017 Nov;40:31-44. doi: 10.1016/j.arr.2017.08.003. Epub 2017 Aug 10. Review. PubMed PMID: 28802803.

18) This systematic review investigated whether the insulin sensitiser metformin has a geroprotective effect in humans. ...

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